DUPLICATE - TO BE DELETED: Uncovering Mechanisms of Protein Multifunctionality

The intracellular virus-host interface of henipaviruses

MN Tripp, SM Rawlinson, SJ Edwards, JM Luczo, GA Marsh, K Halpin, GW Moseley

2025-08-01

The Henipavirus genus comprises five viral species, of which the prototype members, Hendra virus (HeV) and Nipah virus (NiV), are ..

The Replication Function of Rabies Virus P Protein Is Regulated by a Novel Phosphorylation Site in the N-Terminal N Protein-Binding Region

E Tudhope, CM Donnelly, A Sethi, C David, N Williamson, M Stewart, JK Forwood, PR Gooley, GW Moseley

2025-08-01

The rabies virus (RABV) phosphoprotein (P protein) has multiple functions, including acting as the essential non-catalytic cofacto..

Analysis of mechanisms of the rabies virus P protein-nucleocapsid interaction using engineered N-protein peptides and potential applications in antivirals design

J Zhan, S Chakraborty, A Sethi, YF Mok, F Yan, GW Moseley, PR Gooley

2025-02-01

The Phosphoprotein (P protein) of the rabies virus has multiple roles in virus replication. A critical function is to act as a cof..

Conformational dynamics, RNA binding, and phase separation regulate the multifunctionality of rabies virus P protein

SM Rawlinson, S Chakraborty, A Sethi, CT David, AR Harrison, LE Bird, AM Rozario, S Uthishtran, K Ardipradja, T Zhao, S Oksayan, DA Jans, CS Ang, ZH Lu, F Yan, NA Williamson, S Arumugam, V Sundaramoorthy, TDM Bell, PR Gooley

2025-01-01

RNA viruses encode multifunctional proteins to overcome limited genomic capacity and mediate diverse processes in viral replicatio..

Structural insights into the multifunctionality of rabies virus P3 protein

A Sethi, SM Rawlinson, A Dubey, CS Ang, YH Choi, F Yan, K Okada, AM Rozario, AM Brice, N Ito, NA Williamson, DM Hatters, TDM Bell, H Arthanari, GW Moseley, PR Gooley

2023-04-04

Viruses form extensive interfaces with host proteins to modulate the biology of the infected cell, frequently via multifunctional ..

Molecular Basis of Functional Effects of Phosphorylation of the C-Terminal Domain of the Rabies Virus P Protein

J Zhan, E Watts, AM Brice, RD Metcalfe, AM Rozario, A Sethi, F Yan, TDM Bell, MDW Griffin, GW Moseley, PR Gooley

2022-05-01

The rabies virus (RABV) phosphoprotein (P protein) is expressed as several isoforms, which differ in nucleocytoplasmic localizatio..